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A hybrid molecule patterned after N-arachidonoyl serotonin; while saturated 11- or 12-carbon fatty acids linked to serotonin potently inhibit capsaicin-induced TRPV1 channel activation (IC50 = 0.76 μM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC50 > 50 μM), the effects of palmitoyl serotonin are unknown
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A PEGylated derivative of DSPE has been used in CuAAC and SPAAC has been used to attach VCAM-1 antibodies to the surface of liposomes encapsulating fingolimod to provide targeted delivery of fingolimod to inflamed vasculature in a mouse model of post-stroke neuroinflammation has been used to attach FMP to the surface of synthetic platelets used in a mouse model of liver injury-induced uncontrolled hemorrhage
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An oxysterol formed during the metabolic oxidation of cholesterol; used as an internal standard for the quantitative determination of sterols by mass spectroscopic analysis
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The Meso Scale Discovery U-PLEX Human Cystatin C Assay is an electrochemiluminescent immunoassay for the quantitative measurement of Cystatin C in human serum plasma and urine It utilizes MSD s proprietary SULFO-TAG labels and multi-array technology to provide sensitive accurate and rapid quantification of Cystatin C from small sample volumes This assay can aid in the diagnosis and monitoring of kidney function and related diseases It has a measuring range of 50-10 000 pg/mL and exhibits minimal cross-reactivity to related proteins The kit includes a 96-well plate detection antibody calibrator and assay diluent valid for 50 tests
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A symmetric bis-glycolamide that inhibits the eIF2α phosphorylation-mediated unfolded protein response (IC50 = 5 nM in a cell-reporter assay); passes through the blood-brain barrier and significantly enhances learning and memory in mice and rats
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